List of Publications

1. Hümpel M, Frank W
Stimulierung von Kulturen embryonaler Rattenzellen durch Kaelberserum. III. Uridinaufnahme und RNA-Synthese
Zeitschrift fuer Naturforschung, Band 27b, Heft 11, 1399-1404 (1972)

2. Hümpel M
Nucleotidveraenderungen von 18 S und 28 S ribosomaler RNS aus Rattenleber bei der chemischen Carcinogenese durch N-Nitrosomorpholin
Z. Krebsforschung 84: 311-323 (1975)

3. Hümpel M, Kühne G, Schulze P E, Speck U
Injectable depot contraceptives on d-norgestrel basis. I. Pharmacokinetic studies in dog and baboons
Contraception 15 (4): 401-412 (1977)

4. Hümpel M, Wendt H, Schulze P E, Dogs G, Weiß C, Speck U
Bioavailability and pharmacokinetics of cyproterone acetate after oral administration of 2.0 mg cyproterone acetate in combination with 50 µg ethinylestradiol to 6 young women
Contraception 15 (5): 579-588 (1977)

5. Hümpel M, Wendt H, Dogs G, Weiß C, Rietz S, Speck U
Intraindividual comparison of pharmacokinetic parameters of d-norgestrel, lynestrenol and cyproterone acetate in 6 women
Contraception 16 (2): 199-215 (1977)

6. Spona J, Weiner E, Nieuweboer B, Hümpel M
Injectable depot contraceptives on d-norgestrel basis. II. Clinical pharmacokinetic studies with d-norgestrel undecylate in women
Contraception 15 (4): 413-428 (1977)

7. Hümpel M, Wendt H, Pommerenke G, Weiß C, Speck U
Investigations of pharmacokinetics of levonorgestrel to specific consideration of a possible first-pass effect in women
Contraception 17 (3): 207-220 (1978)

8. Hümpel M, Dogs G, Wendt H, Speck U
Plasmaspiegel und Pharmakokinetik von Cyproteronacetat nach oraler Applikation als 50 mg-Tabeltte bei 5 Maennern
Arzneimittel-Forschung (Drug Res.) 28 (I): 2, 319-322 (1978)

9. Düsterberg B, Hümpel M, Wendt H
Plasma levels of active ingredients after single and repeated administration of a new oral contraceptive containing 2 mg of cyproterone acetate and 50 µg of ethinyl estradiol (Diane R) to five young women
Acta Obstet. Gynecol. Scand. Suppl. 88: 27-31 (1979)

10. Elger W, Hasan S H, Hümpel M, Skuballa W, Radüchel B, Vorbrüggen H
The antifertile effects of sulprostone and other prostaglandins and their mechanism of action – a comparative study in several mammalian species.
Int. Sulproston-Symp., Wien, Nov. 1978. In: Med.-wiss. Buchreihe der Schering AG, Berlin/Bergkamen, Berlin 1979

11. Hümpel M, Schulze P E, Speck U
A new principle of injectable depot contraceptives. I. Drug selection and studies in monkeys
Contraception 19 (4): 411-419 (1979)

12. Hümpel M, Pommerenke G, Weiß C
Pharmakokinetik und Metabolismus von Sulproston bei Frauen.
Int. Sulproston-Symposium, Wien, 1978. In: Med.-wiss. Buchreihe der Schering AG, Berlin/Bergkamen, Berlin 1979

13. Hümpel M, Nieuweboer B, Wendt H, Speck U
Investigations of pharmacokinetics of ethinyloestradiol to specific consideration of a possible first-pass effect in women
Contraception 19 (4): 421-432 (1979)

14. Hümpel M, Illi V, Milius W, Wendt H, Kurowski M
The pharmacokinetics and biotransformation of the new benzodiazepine lormetazepam in humans. I. Absorption, distribution, elimination and metabolism of lormetazepam-5-14C.
Eur. J. Drug Metab. Pharmacok. 4: 237-243 (1979)

15. Hümpel M, Nieuweboer B, Düsterberg B, Wendt H
Die Pharmakokinetik von Cyproteronacetat beim Menschen
Excerpta Medica: Androgenisierungserscheinungen bei der Frau (Symposiumsband) (1979)

16. Neumann F, Schleusner A, Hümpel M
Antiandrogene: Pharmakologische Grundlagen
Gynaekologie 12: 228-242 (1979)

17. Girkin R, Baldock G A, Chasseaud L F, Hümpel M, Hawkins D R, Mayo B C
The absorption, distribution and excretion of (14C)-lormetazepam in dogs, rabbits, rats and rhesus monkeys
Xenobiotica 10 (6): 401-411 (1980)

18. Hümpel M, Nieuweboer B, Milius W, Hanke N, Wendt H
Kinetics and biotransformation of lormetazepam. II. Radioimmunologic determinations in plasma and urine of young and elderly subjects: First pass effect
Clin. Pharmacol. Ther. 28 (5): 673-679 (1980)

19. Hümpel M
Relevanz pharmakokinetischer Untersuchungen fuer die klinische Anwendung von Noctamid R
In: Noctamid. Warum ein neues Schlafmittel? Ergebnisse aus Schlafforschung und … (Symposiumsband, Berlin 1980)

20. Mayo B C, Hawkins D R, Hümpel M, Chasseaud L F, Girkin R
The biotransformation of (14C)-lormetazepam in dogs, rabbits, rats and rhesus monkeys
Xenobiotica 10 (6): 413-420 (1980)

21. Nieuweboer B, Hümpel M, Düsterberg B
Farmacocinetica ed attivita biologica di un nuovo progestinico: il gestodene.
Estratto dal volume: Il controllo della fecondita. Atti del IV. Seminario Internazionale (1980), Genf

22. Stoppelli I, Rainer E, Hümpel M
Transfer of cyproterone acetate to the milk of latating women
Contraception 22 (5): 485-493 (1980)

23. Düsterberg B, Hümpel M, Speck U
Terminal half-lives in plasma and bioavailability of norethisterone, levonorgestrel, cyproterone acetate and gestodene in rats, beagles and rhesus monkeys
Contraception 24 (6): 673-683 (1981)

24. Hümpel M, Nieuweboer B, Hasan S H, Wendt H
Radioimmunoassay of plasma lisuride in man following intravenous and oral administration of lisuride hydrogen maleate. Effect on plasma prolactin level
Eur. J. Clin. Pharmacol. 20: 47-51 (1981)

25. Hümpel M, Toda T, Oshino N, Pommerenke G
The pharmacokinetics of lisuride hydrogen maleate in rat, rabbit and rhesus monkey
Eur. J. Drug Metab. Pharmacokin. 6 (3): 207-219 (1981)

26. Kampf D, Hümpel M, Lerche U, Kessel M
Effects of uremia and hemodialysis on lormetazepam disposition
Clin. Pharmacol. Ther. 30 (1): 77-85 (1981)

27. Neumann F, Hümpel M, Senge T, Schenck B, Tunn U
Cyproterone acetate – biochemical and biological basis for treatment of prostatic cancer.
To be published in: Jacobi G.H., Hohenfellner R.F. (Edts): Prostata Cancer, of the book series: International Perspectives in urology, Williams & Wilkins, Col. Baltimore, USA (1981)

28. Hümpel M
Pharmacokinetics and biotransformation of norethisterone in animals. A review.
Contraception 26 (1): 83-95 (1982)

29. Hümpel M, Stoppelli I, Milia S, Rainer E
Pharmacokinetics and biotransformation of the new benzodiazepine, lormetazepam, in man. III. Repeated administration and transfer to neonates via breast milk
Eur. J. Clin. Pharmacol. 21: 421-425 (1982)

30. Hümpel M
Pharmacokinetics of lisuride in animal species and humans.
In. Lisuride and other Dopamine agonists, p. 141-152. Edts. : Calne D.B., Horowski R., McDonald R.J., Wuttke W., Symposiumsband (Int. Workshop on Lisuride and their Dopamine agonists), Raven Press, 1982

31. Hümpel M, Düsterberg B
The role of pharmacokinetics in the development and use of long-acting progestogens
In: Progestogens in Therapy. Edts.: Benagiano G., Zulli P., Diczfalusy E., Serona Symposia Publication from Raven Press, Vol. 3 (1983)

32. Hümpel M, Krause W, Hoyer G-A, Wendt G, Pommerenke G
The pharmacokinetics and biotransformation of 14C-lisuride hydrogen maleate in rhesus monkey and in man
Europ. J. Drug Metab. Pharmacokin. 9 (4): 347-357 (1984)

Krause W, Hümpel M, Hoyer G-A
Biotransformation of the stable prostacyclin analogue, iloprost, in the rat
Drug Metab. Dispos. 12 (5): 645-651 (1984)

33. Täuber U, Hümpel M
Distribution of norethisterone and ethinylestradiol in the gravid rat and in the feto-placental unit of rhesus monkey following intragastric ethinylestradiol. I. Direct determinations
Arzneimittel Forschung (Drug Res.) 34 (I): 440-446 (1984)

34. Täuber U, Hümpel M
Distribution of norethisterone and ethinylestradiol in the gravid rat and in the feto-placental until of rhesus monkey following intragastric administration of norethisterone acetate in combination with ethinylestradiol. II.
Arzneimittel Forschung (Drug Res) 34 (I): 590-596 (1984)

35. Düsterberg B, Schmidt-Gollwitzer M, Hümpel M
Pharmacokinetics and biotransformation of estradiol valerate in ovariectomized women
Hormone Research 21: 145-154 (1985)

36. Krause W, Jakobs U, Schulze P E, Nieuweboer B, Hümpel M
Development of antibody-mediated extraction followed by GC/MS (antibody GC/MS) and its application to iloprost determination in plasma
Prostagland. Leukotr. Med. 17: 167-182 (1985)

37. Hümpel M, Kühne G, Lehmann H, Poggel A
Pharmacokinetically governed design of animal toxicity studies of a new antidepressant drug
Arch. Tox. Suppl. 251 (1986)

38. Hümpel M, Düsterberg B, Beier S, Schuppler J, Günzel P, Elger W
The role of pharmacokinetics in preclinical safety studies of synthetic sex steroids
Contraceptive Steroids, 47-65 (1986)

39. Täuber U, Hümpel M
Distribution of norethisterone (NET) and Ethinylestradiol (EE2) in the gravid rat and in the feto-placental unit of rhesus monkeys following intragastric administration
In: The Intrauterine Life. Management and Therapy. Schenker I.G., Weinsterin D. (Eds.), Excerpta Medica, Amsterdam, New York, Oxford, 361-365 (1986)

40. Hümpel M, Kühne G, Täuber U, Schulze P E
Studies on the kinetics of bis(tris-n-butyl-113-tin)oxide (TBTO)
in: Toxicology and analysis of the tributyltins: The present status (p. 122-150)Proceedings of an ORTEPA workshop, Berlin, 5.-16.5.1986

41. Düsterberg B, Tack J, Krause W, Hümpel M
Pharmacokinetics and biotransformation of gestodene in man
In: Gestodene, ed. by Elstein M., Parthenon Publ., 35-44 (1987)

42. Hildebrand M, Hümpel M, Krause W, Täuber U
Pharmacokinetics of bromerguride, a new dopamine-antagonist ergot-derivative, in rat and dog
Eur. J. Drug Metab. Pharm. 12: 31-40 (1987)

43. Krause W, Hümpel M
Pharmacokinetics of proterguride in the rat and cynomolgus monkey
Xenobiotica 18 (19): 41-48 (1988)

44. Krause W, Hümpel M
Pharmacokinetics of the dopamine partial agonist, terguride, in the rat and rhesus monkey
Eur. J. Drug Metab. Pharmacokin. 13: 185-194 (1988)

45. Huempel M
Options and limitations of animal free methods to study the biotransformation of xenobiotics
Proceedings of the Symposium: Alternatives to animal experiment in risk assessment, Berlin, 26. – 27.3.1987, Sonderdruck 157/88, 65-73 (1988)

46. Hümpel M, Sostarek D, Gieschen H, Labitzky C
Studies on the biotransformation of lonazolac, bromerguride, lisuride, and terguride in laboratory animals and their hepatocytes
Xenobiotica 19 (4): 361-377 (1989)

47. Hümpel M
Comparative pharmacokinetics of selected contraceptive steroids in animal species and man
In: Safety requirements for contraceptive steroids. Michal F. (Edt.), Cambridge University Press, p. 193-210 (1989)

48. Nieuweboer B, Tack J, Täuber U, Hümpel M, Wendet H
Development and application of a radioimmunoassay of the new progestagen gestodene
Contraception 40: 313-323 (1989)

49. Hellstern A, Hildebrand M, Hümpel M, Hellenbrecht D, Saller R, Madetzki C
Minimal biliary excretion and enterohepatic recirculation of lormetazepam in man as investigated by a new nasobiliary drainage technique
Int. J. Clin. Pharmacol. Ther. Tox. 28 (6): 256-261 (1990)

50. Hildebrand M, Hellstern A, Hümpel M, Hellenbrecht D, Saller R
Plasma levels and urinary excretion of lormetazepam in patients with liver cirrhosis and in healthy volunteers
Eur. J. Drug Metab. Pharmacokin. 15: 19-26 (1990)

51. Hümpel M, Täuber U, Kuhnz W, Pfeffer M, Brill K, Heithecker R, Louton T, Steinberg B
Comparison of serum ethinyl estradiol, SHBG, CBG and cortisol levels in women using two low-dosed combined oral contraceptives
Hormone Res. 33: 35-39 (1990)

52. Hümpel M, Täuber U, Kuhnz W, Pfeffer M, Brill K, Heithecker R, Louton T, Steinberg B, Seifert W, Schütt B
Protein binding of active ingredients and comparison of serum ethinyl estradiol sex-hormone-binding globulin, corticosteroid-binding globulin, and cortisol levels in women using a combination of gestodene/ethinyl estradiol (Marvelon) and single-dose ethinyl estradiol bioequivalence from both oral contraceptives
Am. J. Obstet. Gyn. 163 (1): Part 2, 329-333 (1990)

53. Kuhnz W, Hümpel M, Schütt B, Louton T, Steinberg B, Gansau C
Relative bioavailability of ethinyl estradiol from two different oral contraceptive formulations after single oral administration to 18 women in an intraindividual cross-over design
Hormone Res. 33: 40-44 (1990)

54. Qi-Gui L, Hümpel M
Serum protein binding characteristics of cyproterone acetate, gestodene, levonorgestrel and norethisterone in rat, rabbit, dog, monkey and man
J. Steroid. Biochem. 35 (2): 319-326 (1990)

55. Täuber U, Kuhnz W, Hümpel M
Pharmacokinetics of gestodene and ethinyl estradiol after oral administration of a monophasic contraceptive
Am. J. Obstet. Gynecol. 163: 1414-1420 (1990)

56. Hadgraft J, Hill S, Huempel M, Johnston L R, Lever L R, Marks R, Murphy T M, Rapier C
Investigations on the Percutaneous Absorption of the Antidepressant Rolipram in Vitro and in Vivo
Pharmaceutical Research, Vol. 7, No. 12, p. 1307-1312 (1990)

57. Hümpel M, Günzel P, Junginger B
ZK 90 695: A new antiarthritic drug with tissue targeting properties
Agents and Actions 32 ½: 22-23, 1991

58. Qi-Gui L, Ming-Da Z, Hümpel M
Investigations on the in vitro metabolism of five synthetic 19-norprogestins using hepatocyte suspensions isolated from five laboratory animal species
Europ. J. Drug Metab. Pharmacokin. 16 (2): 93-102 (1991)

59. Dibbelt L, Knuppen R, Kuhnz W, Hümpel M, Jütting G
Serum levels and protein binding of gestodene during long term OC use
Acta Endocrinol., Suppl. 4, 83 (1992)

60. Hümpel M
Progestins: In vitro studies and their relevance for the in vivo situation
Klinische Pharmakologie aktuell, 1-92, 3. Jahrgang, Heft 1, 58-60 (1992)

61. Zuo M, Karras D, Hümpel M
Influence of protein binding on the metabolic clearance rate of synthetic progestins in the rat liver perfusion model
Arzneimittel Forschung (Drug Res.) 42 (II), 9, 1130-1138 (1992)

62. Qi-Gui L, Huempel M
Pharmacokinetics, hydrolysis and aromatisation of norethisterone-3-oxime in female cynomolgus monkey
European Journal of Drug Metabolism and Pharmacokinetics, Vol. 17, No. 4, p. 281-291 (1992)

63. Zamah N M, Huempel M, Kuhnz W, Louton T, Rafferty J, Back D J
Absence of an effect of high vitamin C dosage on the systemic availability of ethinyl estradiol in women using a combination oral contraceptive
Contraception 48, p. 377-391 (1993)

64. Hildebrand M, Huempel M, Gieschen H, Kraus C
Xenobiotic Metabolism: From intact biosystem to single enzymes
In: Ernst Schering Research Foundation Workshop 13: Assessment of the use of single cytochrome P450 enzymes in drug research, Edt. Waterman M R, Hildebrand M, Springer-Verlag, 1-19 (1994)

65. Hümpel M
A short review on the source of variability in pharmacokinetic parameters of sex steroids: Comment on the paper by K. Fotherby
Steroid Contraceptives and Women’s Response, Edited by Snow R and Hall P, Plenum Press, New York, 133-141, 1994

66. Heuner A, Kuhnz W, Heger-Mahn D, Richert K, Hümpel M
A single-dose and 3-month clinical-pharmacokinetic study with a new combination oral contraceptive
Advances on Contraception 11: 207-225, 1995

67. Gandon J M, Le Coz F, Kühne G, Hümpel M, Allain H, Pecker J
Pharmacokinetic/pharmacodynamic interaction studies of lisuride with erythromycin and food in healthy volunteers
Clinical Pharmacology & Therapeutics 57: 2, 191 1995

68. Kuhnz W, Louton T, Hümpel M, Back DJ, Zamah N M
Influence of high doses of vitamin C on the bioavailability and the serum protein binding of levonorgestrel in women using a combination oral contraceptive
Contraception 51: 111-116, 1995

69. Kuhnz W, Hümpel M, Biere H, Gross D
Influence of repeated oral doses of ethinyloestradiol on the metabolic disposition of (13C2)-ethinyloestradiol in young women
Eur J Clin Pharmacol 50: 231-235 (1996)

70. Kuhnz W, Heuner A, Hümpel M, Seifert W, Michaelis K
In vivo conversion of norethisterone and norethisterone acetate to ethinyl estradiol in postmenopausal women

71. M. Rad, M. Hümpel, O. Schaefer, R.C. Schoemaker, W-D Schleuning, A.F. Cohen, J. Burggraaf:
Pharmacokinetics and systemic endocrine effects of the phytoestrogen 8-prenylnaringenin after single oral doses to postmenopausal women
British Journal of Clinical Pharmacology 62,3: 288-296 (2006)

72. Schaefer O, Bohlmann R, Schleuning WD, Schulze-Forster K, Hümpel M.
Development of a radioimmunoassay for the quantitative determination of 8-prenylnaringenin in biological matrices. J Agric.Food Chem 2005; 53:2881-2889.

73. Pepper MS, Hazel SJ, Hümpel M, Schleuning W-D,
8-Prenylnaringenin, a novel phytoestrogen, inhibits angiogenesis in vitro and in vivo
J Cell Physiol, 199, 98-107, 2004

74. Schaefer O, Hümpel M, Fritzemeier K-H, Bohlmann R, Schleuning W-D,
8-Prenyl naringenin is a potent ER selective phytoestrogen in hops and beer
J Steroid Biochem Mol Biol 84, 359-360, 2003

75. Hümpel M, Isaksson P, Schaefer O, Kaufmann U, Ciana P, Maggi A, Schleuning W-D:
Tissue specificity of 8-prenylnaringenin: Protection from ovariectomy induced bone loss with minimal trophic effects on the uterus
J Steroid Biochem Mol Biol 97, 299-305, 2005

76. Kutzsche J, Jürgens D, Willuweit A, Adermann K, Fuchs C, Simons S, Windisch M, Hümpel M, Rossberg W, Wolzt M and Willbold D.
Safety and pharmacokinetics of the orally available antiprionic compound PRI-002: A single and multiple ascending dose phase I study. Alzheimers Dement (N Y), 2020. 6(1): p. e12001.

77. Kutzsche J, Schemmert S Bujnicki T, Zafiu C, Halbgebauer S, Kraemer-Schulien V, Pils M, Blömeke L, Post J, Kulawik A, Jürgens D, Rossberg W, Hümpel M, Bannach O, Otto M, Araujo JA, Willuweit A and Willbold D.
Beta-amyloid oligomer disassembly decreases tau oligomer concentration and enhances cognition and memory in aged Beagle dogs. 2022 (submitted)

78. Kutzsche J, Schemmert S Bujnicki T, Zafiu C, Halbgebauer S, Kraemer-Schulien V, Pils M, Blömeke L, Post J, Kulawik A, Jürgens D, Rossberg W, Hümpel M, Bannach O, Otto M, Araujo JA, Willuweit A and Willbold D:
Oral treatment with the all-D-peptide RD2 enhances cognition in aged beagle dogs – A model of sporadic Alzheimer’s disease; Heliyon 9 (2023) eJ 8443